Subunit Vaccine against the Seven Serotypes of Botulism
نویسندگان
چکیده
منابع مشابه
Subunit vaccine against the seven serotypes of botulism.
Botulinum neurotoxins (BoNTs) are the most toxic proteins for humans and are classified as category A toxins. There are seven serotypes of BoNTs defined by the lack of cross-serotype toxin neutralization. Thus, an effective vaccine must neutralize each BoNT serotype. BoNTs are organized as dichain A-B toxins, where the N-terminal domain (light chain) is a zinc metalloprotease targeting soluble ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2008
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.01025-07